VPS13D promotes peroxisome biogenesis.
J Cell Biol
; 220(5)2021 05 03.
Article
em En
| MEDLINE
| ID: mdl-33891012
ABSTRACT
The VPS13 gene family consists of VPS13A-D in mammals. Although all four genes have been linked to human diseases, their cellular functions are poorly understood, particularly those of VPS13D. We generated and characterized knockouts of each VPS13 gene in HeLa cells. Among the individual knockouts, only VPS13D-KO cells exhibit abnormal mitochondrial morphology. Additionally, VPS13D loss leads to either partial or complete peroxisome loss in several transformed cell lines and in fibroblasts derived from a VPS13D mutation-carrying patient with recessive spinocerebellar ataxia. Our data show that VPS13D regulates peroxisome biogenesis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas
/
Peroxissomos
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article