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Activation of V1a vasopressin receptors excite subicular pyramidal neurons by activating TRPV1 and depressing GIRK channels.
Lei, Saobo; Hu, Binqi; Rezagholizadeh, Neda.
Afiliação
  • Lei S; Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, 58203, USA. Electronic address: saobo.lei@und.edu.
  • Hu B; Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, 58203, USA.
  • Rezagholizadeh N; Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, 58203, USA.
Neuropharmacology ; 190: 108565, 2021 06 01.
Article em En | MEDLINE | ID: mdl-33891950
Arginine vasopressin (AVP) is a nonapeptide that serves as a neuromodulator in the brain and a hormone in the periphery that regulates water homeostasis and vasoconstriction. The subiculum is the major output region of the hippocampus and an integral component in the networks that processes sensory and motor cues to form a cognitive map encoding spatial, contextual, and emotional information. Whereas the subiculum expresses high densities of AVP-binding sites and AVP has been shown to increase the synaptic excitability of subicular pyramidal neurons, the underlying cellular and molecular mechanisms have not been determined. We found that activation of V1a receptors increased the excitability of subicular pyramidal neurons via activation of TRPV1 channels and depression of the GIRK channels. V1a receptor-induced excitation of subicular pyramidal neurons required the function of phospholipase Cß, but was independent of intracellular Ca2+ release. Protein kinase C was responsible for AVP-mediated depression of GIRK channels, whereas degradation of phosphatidylinositol 4,5-bisphosphate was involved in V1a receptor-elicited activation of TRPV1 channels. Our results may provide one of the cellular and molecular mechanisms to explain the physiological functions of AVP in the brain.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores de Vasopressinas / Células Piramidais / Canais de Potássio Corretores do Fluxo de Internalização Acoplados a Proteínas G / Canais de Cátion TRPV / Hipocampo Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores de Vasopressinas / Células Piramidais / Canais de Potássio Corretores do Fluxo de Internalização Acoplados a Proteínas G / Canais de Cátion TRPV / Hipocampo Idioma: En Ano de publicação: 2021 Tipo de documento: Article