[External validation of nomogram for the prediction of recurrences of pregnancy-associated breast cancer]. / Cancer du sein associé à la grossesse : validation d'un nomogramme prédictif de la récidive.
Gynecol Obstet Fertil Senol
; 49(11): 844-849, 2021 Nov.
Article
em Fr
| MEDLINE
| ID: mdl-33892161
ABSTRACT
OBJECTIVE:
Diagnosis and therapeutics are challenging in pregnancy-related breast cancer and a multidisciplinary approach is therefore essential. A nomogram predictive of recurrence at 36 months of PABC has recently been developed, the aim was to evaluate it on an independent cohort. PATIENTS ANDMETHODS:
This was a monocentric retrospective study including all patients with PABC between January 2004 and March 2018. A Kaplan-Meier method was used for the analysis of recurrence-free survival. Nomogram performance was analysed on 3 indicators discrimination by a receiver operator characteristic curve (ROC), calibration and net clinical benefit by a decision curve analysis.RESULTS:
Forty-one patients have been included. The survival rate was 83 % at 3 years. The nomogram showed acceptable discrimination capacities on receiver-operator characteristic analysis (c-index 0.78). Decision-curve analysis showed a positive net-benefit for relapse probability ranges between 5 % and 35 %.CONCLUSION:
The performance of this prediction model is acceptable but the net clinical benefit low. In conclusion, prediction of recurrence remains challenging with a continued need for more precise tools.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Nomogramas
Idioma:
Fr
Ano de publicação:
2021
Tipo de documento:
Article