Safety evaluation of fermented Platycodon grandiflorus (Jacq.) A.DC. extract: Genotoxicity, acute toxicity, and 13-week subchronic toxicity study in rats.

Jung, Jin A; Noh, Jung-Ho; Jang, Min Seong; Gu, Eun-Young; Cho, Min-Kyung; Lim, Kwang-Hyun; Park, Heejin; Back, Seng-Min; Kim, Sung Phil; Han, Kang-Hyun

Jung, Jin A; Noh, Jung-Ho; Jang, Min Seong; Gu, Eun-Young; Cho, Min-Kyung; Lim, Kwang-Hyun; Park, Heejin; Back, Seng-Min; Kim, Sung Phil; Han, Kang-Hyun.

Afiliação

Jung JA; Department of Advanced Toxicology Research, Korea Institute of Toxicology, 141 Gajeong-ro, Yuseong-gu, Daejeon, 34114, Republic of Korea.
Noh JH; Department of Advanced Toxicology Research, Korea Institute of Toxicology, 141 Gajeong-ro, Yuseong-gu, Daejeon, 34114, Republic of Korea.
Jang MS; Department of Advanced Toxicology Research, Korea Institute of Toxicology, 141 Gajeong-ro, Yuseong-gu, Daejeon, 34114, Republic of Korea.
Gu EY; Department of Advanced Toxicology Research, Korea Institute of Toxicology, 141 Gajeong-ro, Yuseong-gu, Daejeon, 34114, Republic of Korea.
Cho MK; Department of Advanced Toxicology Research, Korea Institute of Toxicology, 141 Gajeong-ro, Yuseong-gu, Daejeon, 34114, Republic of Korea.
Lim KH; Department of Advanced Toxicology Research, Korea Institute of Toxicology, 141 Gajeong-ro, Yuseong-gu, Daejeon, 34114, Republic of Korea.
Park H; Department of Advanced Toxicology Research, Korea Institute of Toxicology, 141 Gajeong-ro, Yuseong-gu, Daejeon, 34114, Republic of Korea.
Back SM; Department of Advanced Toxicology Research, Korea Institute of Toxicology, 141 Gajeong-ro, Yuseong-gu, Daejeon, 34114, Republic of Korea.
Kim SP; STR Biotech Co., Ltd., Chuncheon, 24232, Republic of Korea.
Han KH; Department of Advanced Toxicology Research, Korea Institute of Toxicology, 141 Gajeong-ro, Yuseong-gu, Daejeon, 34114, Republic of Korea. Electronic address: hankh@kitox.re.kr.

J Ethnopharmacol ; 275: 114138, 2021 Jul 15.

Article em En | MEDLINE | ID: mdl-33895248

Assuntos

Dano ao DNA/efeitos dos fármacos; Extratos Vegetais/toxicidade; Platycodon/química; Administração Oral; Animais; Peso Corporal/efeitos dos fármacos; Células da Medula Óssea/efeitos dos fármacos; Aberrações Cromossômicas/efeitos dos fármacos; Cricetulus; Ingestão de Alimentos/efeitos dos fármacos; Escherichia coli/efeitos dos fármacos; Feminino; Fermentação; Rim/efeitos dos fármacos; Rim/patologia; Pulmão/efeitos dos fármacos; Masculino; Testes para Micronúcleos; Testes de Mutagenicidade; Nível de Efeito Adverso não Observado; Tamanho do Órgão/efeitos dos fármacos; Extratos Vegetais/administração & dosagem; Extratos Vegetais/química; Ratos Sprague-Dawley; Salmonella typhimurium/efeitos dos fármacos; Testes de Toxicidade Aguda; Testes de Toxicidade Subcrônica

Palavras-chave

Acute toxicity; Genotoxicity; No observed adverse effect level; Platycodon grandiflorus (Jacq.) A.DC.; Subchronic toxicity

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dano ao DNA / Extratos Vegetais / Platycodon Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dano ao DNA / Extratos Vegetais / Platycodon Idioma: En Ano de publicação: 2021 Tipo de documento: Article