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Atypical antipsychotics in the treatment of psychotic symptoms in Alzheimer's disease: a systematic review.
Vinasi, Ramona; Buciuta, Andrei; Coman, Horia George.
Afiliação
  • Vinasi R; Department of Psychiatry.
  • Buciuta A; Department of Cellular and Molecular Biology.
  • Coman HG; Department of Medical Psychology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Int Clin Psychopharmacol ; 36(4): 169-180, 2021 07 01.
Article em En | MEDLINE | ID: mdl-33902085
With the advancement of Alzheimer's disease as well as other types of dementia, in addition to the cognitive decline, psychiatric symptoms have been outlined, including psychotic symptoms. The aim of the study is to review the available results on the antipsychotic treatment of Alzheimer's disease associated psychotic symptoms. The main objective of the study is to evaluate the efficacy of the treatment. The second objective is to assess the tolerability of this treatment. Double-blind, randomized, placebo-controlled trials, which took place over the course of at least 4 weeks, have been searched. Studies that compared one atypical antipsychotic to placebo, as well as more atypical antipsychotics, compared one to another, have been taken into account. In total 17 studies have been selected. The efficacy of the atypical antipsychotics has proven to be significant in most studies. Moreover, antipsychotic medication, such as risperidone, aripiprazole, olanzapine, quetiapine and pimavanserin, has been well tolerated. Atypical antipsychotics are the treatment of choice for psychotic symptoms in dementia. Despite the consistent results present in the literature up to this point, various antipsychotics remain insufficiently studied and would need more generous sample sizes for their outcomes to be substantiated.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtornos Psicóticos / Antipsicóticos / Doença de Alzheimer Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtornos Psicóticos / Antipsicóticos / Doença de Alzheimer Idioma: En Ano de publicação: 2021 Tipo de documento: Article