Gold-catalyzed synthesis of 1H-isochromene-4-carbaldehydes via oxidative cascade cyclization.
Org Biomol Chem
; 19(16): 3634-3643, 2021 04 28.
Article
em En
| MEDLINE
| ID: mdl-33908556
ABSTRACT
An efficient gold-catalyzed formation of indenylidene-derived 1H-isochromene-4-carbaldehydes from substituted 1,5,10-triyne-O-silanes was developed under mild reaction conditions. In this reaction, gold-catalyzed selective oxidation, 1,2-migration, nucleophilic addition and then 5-endo-dig cyclization took place regioselectively. The indenylidene-derived isochromene-4-carbaldehydes were synthesized in moderate to very good yields via the formation of new C-C and C-O bonds in one pot.
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MEDLINE
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En
Ano de publicação:
2021
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Article