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Pathological polyQ expansion does not alter the conformation of the Huntingtin-HAP40 complex.
Huang, Bin; Guo, Qiang; Niedermeier, Marie L; Cheng, Jingdong; Engler, Tatjana; Maurer, Melanie; Pautsch, Alexander; Baumeister, Wolfgang; Stengel, Florian; Kochanek, Stefan; Fernández-Busnadiego, Rubén.
Afiliação
  • Huang B; Department of Gene Therapy, Ulm University, 89081, Ulm, Germany.
  • Guo Q; Department of Molecular Structural Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany; State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences and Peking-Tsinghua Center for Life Sciences, Peking University, 100871 Beijing, China.
  • Niedermeier ML; Department of Biology, University of Konstanz, 78457 Konstanz, Germany; Konstanz Research School Chemical Biology, University of Konstanz, 78457 Konstanz, Germany.
  • Cheng J; Gene Center, Department of Biochemistry and Center for Integrated Protein Science Munich, Ludwig-Maximilians University, 81377 Munich, Germany.
  • Engler T; Department of Gene Therapy, Ulm University, 89081, Ulm, Germany.
  • Maurer M; Department of Medicinal Chemistry, Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach an der Riß, Germany.
  • Pautsch A; Department of Medicinal Chemistry, Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach an der Riß, Germany.
  • Baumeister W; Department of Molecular Structural Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany.
  • Stengel F; Department of Biology, University of Konstanz, 78457 Konstanz, Germany; Konstanz Research School Chemical Biology, University of Konstanz, 78457 Konstanz, Germany. Electronic address: florian.stengel@uni-konstanz.de.
  • Kochanek S; Department of Gene Therapy, Ulm University, 89081, Ulm, Germany. Electronic address: stefan.kochanek@uni-ulm.de.
  • Fernández-Busnadiego R; Department of Molecular Structural Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany; Institute of Neuropathology, University Medical Center Göttingen, 37099 Göttingen, Germany; Cluster of Excellence "Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cel
Structure ; 29(8): 804-809.e5, 2021 08 05.
Article em En | MEDLINE | ID: mdl-33909994
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos / Proteínas Nucleares / Doença de Huntington / Proteína Huntingtina Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos / Proteínas Nucleares / Doença de Huntington / Proteína Huntingtina Idioma: En Ano de publicação: 2021 Tipo de documento: Article