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Positive Effects of Oral Antibiotic Administration in Murine Chronic Graft-Versus-Host Disease.
Sato, Shinri; Shimizu, Eisuke; He, Jingliang; Ogawa, Mamoru; Asai, Kazuki; Yazu, Hiroyuki; Rusch, Robert; Yamane, Mio; Yang, Fan; Fukuda, Shinji; Kawakami, Yutaka; Tsubota, Kazuo; Ogawa, Yoko.
Afiliação
  • Sato S; Department of Ophthalmology, Keio University School of Medicine, Tokyo 160-8582, Japan.
  • Shimizu E; Department of Ophthalmology, Keio University School of Medicine, Tokyo 160-8582, Japan.
  • He J; Department of Ophthalmology, Keio University School of Medicine, Tokyo 160-8582, Japan.
  • Ogawa M; Aier Eye school of Ophthalmology, Central South University, Changsha 410083, China.
  • Asai K; Department of Ophthalmology, Keio University School of Medicine, Tokyo 160-8582, Japan.
  • Yazu H; Department of Ophthalmology, Keio University School of Medicine, Tokyo 160-8582, Japan.
  • Rusch R; Department of Ophthalmology, Keio University School of Medicine, Tokyo 160-8582, Japan.
  • Yamane M; Department of Ophthalmology, Tsurumi University School of Dental Medicine, Kanagawa 230-0063, Japan.
  • Yang F; Department of Ophthalmology, Keio University School of Medicine, Tokyo 160-8582, Japan.
  • Fukuda S; Department of Ophthalmology, Keio University School of Medicine, Tokyo 160-8582, Japan.
  • Kawakami Y; Department of Ophthalmology, Keio University School of Medicine, Tokyo 160-8582, Japan.
  • Tsubota K; Aier Eye school of Ophthalmology, Central South University, Changsha 410083, China.
  • Ogawa Y; Institute for Advanced Biosciences, Keio University, Yamagata 997-0052, Japan.
Int J Mol Sci ; 22(7)2021 Apr 03.
Article em En | MEDLINE | ID: mdl-33916809
ABSTRACT
Chronic graft-versus-host disease (cGVHD) is one of the most frequent complications experienced after allogeneic hematopoietic stem cell transplantation. Reportedly, dysbiosis and severe damage to the microbiome are also closely associated with GVHD. Herein, we aimed to elucidate the positive and negative effects of the administration of various antibiotics in a murine model of cGVHD. For allogeneic bone marrow transplantation (allo-BMT), bone marrow from B10.D2 mice were transplanted in BALB/c mice to induce cGVHD. The cGVHD mice were orally administered ampicillin, gentamicin (GM), fradiomycin, vancomycin, or the solvent vehicle (control group). Among the antibiotic-treated mice, the systemic cGVHD phenotypes and ocular cGVHD manifestations were suppressed significantly in GM-treated mice compared to that in control mice. Inflammatory cell infiltration and fibrosis in cGVHD-targeted organs were significantly attenuated in GM-treated mice. Although regulatory T cells were retained at greater levels in GM-treated mice, there were significantly fewer Th17 cells and interleukin (IL)-6-producing macrophages in cGVHD-targeted organs in these mice. Collectively, our results revealed that orally administered GM may exert positive effects in a cGVHD mouse model.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transplante de Medula Óssea / Doença Enxerto-Hospedeiro / Antibacterianos Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transplante de Medula Óssea / Doença Enxerto-Hospedeiro / Antibacterianos Idioma: En Ano de publicação: 2021 Tipo de documento: Article