Cell Force-Driven Basement Membrane Disruption Fuels EGF- and Stiffness-Induced Invasive Cell Dissemination from Benign Breast Gland Acini.

Gaiko-Shcherbak, Aljona; Eschenbruch, Julian; Kronenberg, Nils M; Teske, Michael; Wolters, Benjamin; Springer, Ronald; Gather, Malte C; Merkel, Rudolf; Hoffmann, Bernd; Noetzel, Erik

Gaiko-Shcherbak, Aljona; Eschenbruch, Julian; Kronenberg, Nils M; Teske, Michael; Wolters, Benjamin; Springer, Ronald; Gather, Malte C; Merkel, Rudolf; Hoffmann, Bernd; Noetzel, Erik.

Afiliação

Gaiko-Shcherbak A; Institute of Biological Information Processing 2 (IBI-2): Mechanobiology, Forschungszentrum Jülich, 52425 Jülich, Germany.
Eschenbruch J; Institute of Biological Information Processing 2 (IBI-2): Mechanobiology, Forschungszentrum Jülich, 52425 Jülich, Germany.
Kronenberg NM; SUPA, School of Physics and Astronomy, University of St Andrews, St Andrews KY16 9SS, UK.
Teske M; Humboldt Centre for Nano- and Biophotonics, Department of Chemistry, Universität zu Köln, 50939 Köln, Germany.
Wolters B; Institute of Biological Information Processing 2 (IBI-2): Mechanobiology, Forschungszentrum Jülich, 52425 Jülich, Germany.
Springer R; Institute of Biological Information Processing 2 (IBI-2): Mechanobiology, Forschungszentrum Jülich, 52425 Jülich, Germany.
Gather MC; Institute of Biological Information Processing 2 (IBI-2): Mechanobiology, Forschungszentrum Jülich, 52425 Jülich, Germany.
Merkel R; SUPA, School of Physics and Astronomy, University of St Andrews, St Andrews KY16 9SS, UK.
Hoffmann B; Humboldt Centre for Nano- and Biophotonics, Department of Chemistry, Universität zu Köln, 50939 Köln, Germany.
Noetzel E; Institute of Biological Information Processing 2 (IBI-2): Mechanobiology, Forschungszentrum Jülich, 52425 Jülich, Germany.

Int J Mol Sci ; 22(8)2021 Apr 12.

Article em En | MEDLINE | ID: mdl-33921304

Assuntos

Mama/metabolismo; Fator de Crescimento Epidérmico/genética; Neoplasias/genética; Células Acinares/metabolismo; Células Acinares/patologia; Membrana Basal/metabolismo; Membrana Basal/patologia; Mama/patologia; Linhagem Celular Tumoral; Receptores ErbB/genética; Matriz Extracelular/genética; Matriz Extracelular/patologia; Feminino; Humanos; Glândulas Mamárias Humanas/patologia; Fenômenos Mecânicos; Invasividade Neoplásica/genética; Neoplasias/patologia; Pseudópodes/genética; Pseudópodes/patologia

Palavras-chave

basement membrane; breast cancer invasion; cell force; filopodia; mechanically driven cancer progression; mechanobiology; mechanosensing; mechanosensory transduction; neoplasm invasion

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Mama / Fator de Crescimento Epidérmico / Neoplasias Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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