Brown Adipose Tissue: New Challenges for Prevention of Childhood Obesity. A Narrative Review.
Nutrients
; 13(5)2021 Apr 24.
Article
em En
| MEDLINE
| ID: mdl-33923364
ABSTRACT
Pediatric obesity remains a challenge in modern society. Recently, research has focused on the role of the brown adipose tissue (BAT) as a potential target of intervention. In this review, we revised preclinical and clinical works on factors that may promote BAT or browning of white adipose tissue (WAT) from fetal age to adolescence. Maternal lifestyle, type of breastfeeding and healthy microbiota can affect the thermogenic activity of BAT. Environmental factors such as exposure to cold or physical activity also play a role in promoting and activating BAT. Most of the evidence is preclinical, although in clinic there is some evidence on the role of omega-3 PUFAs (EPA and DHA) supplementation on BAT activation. Clinical studies are needed to dissect the early factors and their modulation to allow proper BAT development and functions and to prevent onset of childhood obesity.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Tecido Adiposo Marrom
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Dieta
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Obesidade Infantil
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Microbioma Gastrointestinal
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article