Screening of in vitro and in silico &#945;-amylase, &#945;-glucosidase, and lipase inhibitory activity of oxyprenylated natural compounds and semisynthetic derivatives.

Faraone, Immacolata; Russo, Daniela; Genovese, Salvatore; Milella, Luigi; Monné, Magnus; Epifano, Francesco; Fiorito, Serena

Screening of in vitro and in silico α-amylase, α-glucosidase, and lipase inhibitory activity of oxyprenylated natural compounds and semisynthetic derivatives.

Faraone, Immacolata; Russo, Daniela; Genovese, Salvatore; Milella, Luigi; Monné, Magnus; Epifano, Francesco; Fiorito, Serena.

Afiliação

Faraone I; Department of Science, University of Basilicata, via dell'Ateneo Lucano 10, 85100, Potenza, Italy; SpinoffBioActiPlant s.r.l., via dell'Ateneo Lucano 10, 85100, Potenza, Italy.
Russo D; Department of Science, University of Basilicata, via dell'Ateneo Lucano 10, 85100, Potenza, Italy; SpinoffBioActiPlant s.r.l., via dell'Ateneo Lucano 10, 85100, Potenza, Italy.
Genovese S; Department of Pharmacy, University Gabriele D'Annunzio of Chieti-Pescara, Via dei Vestini 31, 66100, Chieti Scalo, CH, Italy.
Milella L; Department of Science, University of Basilicata, via dell'Ateneo Lucano 10, 85100, Potenza, Italy. Electronic address: luigi.milella@unibas.it.
Monné M; Department of Science, University of Basilicata, via dell'Ateneo Lucano 10, 85100, Potenza, Italy.
Epifano F; Department of Pharmacy, University Gabriele D'Annunzio of Chieti-Pescara, Via dei Vestini 31, 66100, Chieti Scalo, CH, Italy. Electronic address: francesco.epifano@unich.it.
Fiorito S; Department of Pharmacy, University Gabriele D'Annunzio of Chieti-Pescara, Via dei Vestini 31, 66100, Chieti Scalo, CH, Italy.

Phytochemistry ; 187: 112781, 2021 Jul.

Article em En | MEDLINE | ID: mdl-33930668

Assuntos

alfa-Amilases; alfa-Glucosidases; Simulação por Computador; Inibidores de Glicosídeo Hidrolases/farmacologia; Lipase; Simulação de Acoplamento Molecular

Palavras-chave

Metabolic syndrome; Molecular docking; Oxyprenylated natural compounds; Pancreatic lipase inhibition; Semisynthetic compounds; αamylase inhibition; αglucosidase inhibition

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Alfa-Amilases / Alfa-Glucosidases Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo

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PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Alfa-Amilases / Alfa-Glucosidases Idioma: En Ano de publicação: 2021 Tipo de documento: Article