ABO Blood Incompatibility Positively Affects Early Graft Function: Single-Center Retrospective Cohort Study.
Transplant Proc
; 53(5): 1494-1500, 2021 Jun.
Article
em En
| MEDLINE
| ID: mdl-33931247
ABSTRACT
BACKGROUND:
We investigated the association between ABO-incompatible (ABO-I) kidney transplantation and early graft function.METHODS:
We retrospectively analyzed 95 patients who underwent living donor kidney transplantation between May 2009 and July 2019. It included 61 ABO-compatible (ABO-C) and 34 ABO-I transplantations. We extracted data on immunologic profile, sex, age, cold ischemic time, type of immunosuppression, and graft function. Two definitions were used for slow graft function (SGF) as follows postoperative day (POD) 3 serum creatinine level >3 mg/dL and estimated glomerular filtration rate (eGFR) <20 mL/min/1.73 m2. Logistic regression analysis was performed to analyze the effect of ABO-I on the incidence of SGF.RESULTS:
The characteristics between the ABO-C and ABO-I were not different. ABO-I received rituximab and plasma exchange. Patients also received tacrolimus and mycophenolate mofetil for 2 weeks and prednisolone for 1 week before transplantation as preconditioning. Of the 95 study patients, 19 (20%) and 21 (22%) were identified with SGF according to POD 3 serum creatinine level or eGFR, respectively. Multivariable analysis revealed that ABO-I significantly reduced the incidence of SGF (odds ratio, 0.15; 95% confidence interval, 0.03-0.7; P = .02), and cold ischemic time >150 min increased the incidence of SGF (odds ratio, 6.5; 95% confidence interval, 1.7-25; P = .006). Similar results were identified in POD 3 eGFR. Inferior graft function in patients with SGF was identified up to 6 months after transplantation.CONCLUSION:
ABO-I reduces the incidence of SGF, which is associated with an inferior graft function up to 6 months.
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Base de dados:
MEDLINE
Assunto principal:
Incompatibilidade de Grupos Sanguíneos
/
Transplante de Rim
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Função Retardada do Enxerto
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Sobrevivência de Enxerto
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article