Rectal absorption enhancement of rate-controlled delivered ampicillin sodium by sodium decanoate in conscious rats.
Pharm Weekbl Sci
; 10(2): 76-9, 1988 Apr 22.
Article
em En
| MEDLINE
| ID: mdl-3393421
ABSTRACT
Because of the relatively poor intestinal absorption of ampicillin sodium, efforts have been made to enhance ampicillin absorption by co-administration of absorption promoters. In the present study the enhancing effect of sodium decanoate on rate and extent of rectal ampicillin absorption in rats has been evaluated after rate-controlled and site-controlled delivery of aqueous solutions. Rectal absorption without enhancer was extremely low (8 +/- 7%), and the addition of 0.032 M sodium decanoate gave comparable values. However, administration in 0.16 M decanoate considerably increased ampicillin bioavailability, to 79 +/- 30%, whereas the absorption rate was not significantly affected.
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Base de dados:
MEDLINE
Assunto principal:
Decanoatos
/
Ácidos Decanoicos
/
Ampicilina
/
Absorção Intestinal
Idioma:
En
Ano de publicação:
1988
Tipo de documento:
Article