Dorsal vagal nucleus involvement relates to QTc-prolongation after acute medullary infarction.
Acta Neurol Scand
; 144(3): 283-287, 2021 Sep.
Article
em En
| MEDLINE
| ID: mdl-33939183
ABSTRACT
BACKGROUND:
Infarction of the medulla has been associated with prolongation of the QTc, severe arrhythmia, and sudden cardiac death, yet the precise anatomical substrate remains uncertain.AIMS:
We sought to determine the possible anatomical structures relating to QTc-prolongation in patients with acute medullary infarction.METHODS:
We included 12 subjects with acute ischemic medullary infarction on brain MRI, who presented within 4.5 h from the last known well time, with a 90-day follow-up. For an unbiased lesion analysis, medullary infarcts were manually outlined on diffusion weighted MRI and co-registered with an anatomical atlas.RESULTS:
Nine out of 12 had QTc-prolongation. Qualitative and semi-quantitative comparisons were made between infarct location and QTc-prolongation. Among patients with QTc-prolongation, the greatest degree of congruence of the infarct location was over the dorsal vagal nucleus (DVN, 8 out of 9). There was a significant correlation between the number of sections showing infarction of the DVN and presence of QTc-prolongation (r = .582, p = .047). Among patients without QTc-prolongation, the maximum lesion overlap included the medial aspect of the gigantocelluar reticular nucleus of the reticular formation.CONCLUSION:
We found that the DVN is a key anatomical substrate related to QTc-prolongation. Further studies with more patients and high-resolution, volumetric MRI are needed to confirm our findings.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Síndrome do QT Longo
/
Eletrocardiografia
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article