Perioperative Factor Concentrate Use is Associated With More Beneficial Outcomes and Reduced Complication Rates Compared With a Pure Blood Product-Based Strategy in Patients Undergoing Elective Cardiac Surgery: A Propensity Score-Matched Cohort Study.
J Cardiothorac Vasc Anesth
; 36(1): 138-146, 2022 01.
Article
em En
| MEDLINE
| ID: mdl-33941446
ABSTRACT
OBJECTIVE:
The goal of this study was to compare factor concentrate (FC)-based and blood product-based hemostasis management of coagulopathy in cardiac surgical patients in terms of postoperative bleeding, required blood products, and outcome.DESIGN:
Retrospective, propensity score-matched analysis.SETTING:
Single, tertiary, academic medical center.PARTICIPANTS:
One hundred eighteen matched pairs of 433 consecutive patients scheduled for cardiac surgery in two isolated periods with distinct strategies of hemostasis management.INTERVENTIONS:
Patients received either blood product-based (period I) or FC-based (period II) hemostasis management to treat perioperative coagulopathy. MEASUREMENTS AND MAINRESULTS:
Patients treated with FC management experienced less postoperative blood loss (907 v 1,153 mL, pâ¯=â¯0.014) and required less red blood cell and fresh frozen plasma transfusion (2.3 v 3.7 units p < 0.0001, and 2.0 v 3.4 units p < 0.0001, respectively) compared with subjects in the blood product-based management group. The frequency of Stage 3 acute kidney injury and 30-day mortality rate were significantly higher in the blood product-based group than in the FC management group (6.8% v 0.8%, pâ¯=â¯0.016, and 7.2% v 0.8%, pâ¯=â¯0.022, respectively). FC management-related thromboembolic events were not registered. The FC strategy was associated with a 2.19-fold decrease in the odds of massive postoperative bleeding (p < 0.0001), a 2.56-fold decrease in the odds of polytransfusion (p < 0.0001), and a 13.16-fold decrease in the odds of early postoperative death (pâ¯=â¯0.003).CONCLUSIONS:
FC-based versus blood product-based management is associated with reduced blood product needs and fewer complications, and was not linked to a higher frequency of thromboembolic events or a decrease in long-term survival in cardiac surgical patients developing perioperative coagulopathy and bleeding.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transfusão de Componentes Sanguíneos
/
Procedimentos Cirúrgicos Cardíacos
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article