A flow cytometric assay to detect platelet-activating antibodies in VITT after ChAdOx1 nCov-19 vaccination.
Blood
; 137(26): 3656-3659, 2021 07 01.
Article
em En
| MEDLINE
| ID: mdl-33945605
ABSTRACT
Vaccination is crucial in combatting the severe acute respiratory syndrome coronavirus 2 pandemic. The rare complication of thrombocytopenia and thrombotic complications at unusual sites after ChAdOx1 nCov-19 vaccination is caused by platelet-activating antibodies directed against platelet factor 4 (PF4). We present a widely applicable whole-blood standard flow cytometric assay to identify the pathogenic antibodies associated with vaccine-induced immune-mediated thrombotic thrombocytopenia (VITT) after ChAdOx1 nCov-19 vaccination. This assay will enable rapid diagnosis by many laboratories. This trial was registered at www.clinicaltrials.gov as #NCT04370119.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Autoanticorpos
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Imunoglobulina G
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Fator Plaquetário 4
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Ativação Plaquetária
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Vacinação
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Púrpura Trombocitopênica Idiopática
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Receptores de IgG
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Citometria de Fluxo
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Vacinas contra COVID-19
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SARS-CoV-2
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article