Hypoxia-inducible CAR expression: An answer to the on-target/off-tumor dilemma?
Cell Rep Med
; 2(4): 100244, 2021 04 20.
Article
em En
| MEDLINE
| ID: mdl-33948575
On-target/off-tumor toxicity is one of the major concerns regarding CAR T-cell therapy. Kosti et al.1 demonstrate that this form of toxicity can be prevented by designing a CAR whose expression is controlled by oxygen levels in the tumor environment.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Imunoterapia Adotiva
/
Hipóxia
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article