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The effect of RAAS inhibitors on acute hypoxemic respiratory failure and in-hospital mortality in the hypertensive Covid-19 patients.
Akyüz, Abdurrahman; Isik, Ferhat; Aslan, Burhan; Çap, Murat; Kaya, Ilyas; Atli, Özgür; Inci, Ümit; Tastan, Ercan; Aktan, Adem; Bilge, Önder; Oksul, Metin; Aydin, Emre; Karahan, Zülküf; Altintas, Derya Deniz; Altindag, Rojhat; Adiyaman, Mehmet Sahin; Altintas, Bernas.
Afiliação
  • Akyüz A; Department of Cardiology, University of Health Sciences Diyarbakir Gazi Yasargil Education and Research Hospital, Diyarbakir, Turkey.
  • Isik F; Department of Cardiology, University of Health Sciences Diyarbakir Gazi Yasargil Education and Research Hospital, Diyarbakir, Turkey.
  • Aslan B; Department of Cardiology, University of Health Sciences Diyarbakir Gazi Yasargil Education and Research Hospital, Diyarbakir, Turkey.
  • Çap M; Department of Cardiology, University of Health Sciences Diyarbakir Gazi Yasargil Education and Research Hospital, Diyarbakir, Turkey.
  • Kaya I; Department of Cardiology, University of Health Sciences Diyarbakir Gazi Yasargil Education and Research Hospital, Diyarbakir, Turkey.
  • Atli Ö; Department of Chest Diseases, University of Health Sciences Diyarbakir Gazi Yasargil Education and Research Hospital, Diyarbakir, Turkey.
  • Inci Ü; Department of Cardiology, University of Health Sciences Diyarbakir Gazi Yasargil Education and Research Hospital, Diyarbakir, Turkey.
  • Tastan E; Department of Cardiology, University of Health Sciences Diyarbakir Gazi Yasargil Education and Research Hospital, Diyarbakir, Turkey.
  • Aktan A; Department of Cardiology, Mardin State Hospital, Mardin, Turkey.
  • Bilge Ö; Department of Cardiology, University of Health Sciences Diyarbakir Gazi Yasargil Education and Research Hospital, Diyarbakir, Turkey.
  • Oksul M; Department of Cardiology, University of Health Sciences Diyarbakir Gazi Yasargil Education and Research Hospital, Diyarbakir, Turkey.
  • Aydin E; Department of Nefrology, School of Medicine, Dicle University, Diyarbakir, Turkey.
  • Karahan Z; Department of Cardiology, University of Health Sciences Diyarbakir Gazi Yasargil Education and Research Hospital, Diyarbakir, Turkey.
  • Altintas DD; Department of Radiology, University of Health Sciences Diyarbakir Gazi Yasargil Education and Research Hospital, Diyarbakir, Turkey.
  • Altindag R; Department of Cardiology, University of Health Sciences Diyarbakir Gazi Yasargil Education and Research Hospital, Diyarbakir, Turkey.
  • Adiyaman MS; Department of Cardiology, University of Health Sciences Diyarbakir Gazi Yasargil Education and Research Hospital, Diyarbakir, Turkey.
  • Altintas B; Department of Cardiology, University of Health Sciences Diyarbakir Gazi Yasargil Education and Research Hospital, Diyarbakir, Turkey.
Clin Exp Hypertens ; 43(7): 587-596, 2021 Oct 03.
Article em En | MEDLINE | ID: mdl-33955313
INTRODUCTION: We have aimed to investigate the relationship between use of angiotensin-converting-enzyme inhibitor (ACEI) or angiotensin-receptor-blocker (ARB) drugs and acute hypoxemic respiratory failure (AHRF) and in-hospital mortality in hypertensive Covid-19 patients. MATERIAL AND METHOD: Consecutive 1345 patients diagnosed with Covid-19 between April and October 2020 who met inclusion criteria were divided into two groups based on presence and absence of AHRF and mortality. The groups were compared regarding epidemiological, clinical, radiological, laboratory findings and treatments methods. The patient groups ACEI, ARB and other antihypertensive drugs (non-ACEI/ARB) were compared regarding same parameters. RESULTS: Median age was 68 (60-76) years in the patient group including 805 (59.9.1%) females. Of the patients, 475 (35.3%), 644 (47.9%) and 226 (16.8%) were using ACEIs, ARBs and non-ACEI/ARB, respectively. AHRF and in-hospital mortality developed in 1053 (78.3%) and 290 (21.6%) patients, respectively. Age, gender, coronary artery disease, diabetes mellitus (DM), neutrophil, lymphocyte, creatinine, D-dimer, C-reactive protein (CRP), ACEI, beta blocker and aspartate transaminase (AST) found statistically significant in the univariable logistic regression performed to identify independent predictors of mortality were included multivariable logistic regression model. Age (OR: 1.066, 95%CI: 1.049-1.083; p < .001), DM (OR: 1.682, 95%CI: 1.238-2.286; p = .001), neutrophil (OR: 1.041, 95%CI: 1.007-1.077; p = .019), creatinine (OR: 1.178, 95%CI: 1.048-1.325; p = .006), CRP (OR: 1.008, 95%CI: 1.006-1.010; p < .001), ACEI (OR: 0.718, 95%CI: 0.521-0.988; p = .042), AST (OR: 1.005, 95%CI: 1.001-1.010; p = .010) were found associated with in-hospital mortality. CONCLUSION: In our study, it was not detected clinically significant difference between three groups with regard to their relation with in-hospital mortality.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Insuficiência Respiratória / Inibidores da Enzima Conversora de Angiotensina / Mortalidade Hospitalar / Antagonistas de Receptores de Angiotensina / COVID-19 / Tratamento Farmacológico da COVID-19 / Hipertensão Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Insuficiência Respiratória / Inibidores da Enzima Conversora de Angiotensina / Mortalidade Hospitalar / Antagonistas de Receptores de Angiotensina / COVID-19 / Tratamento Farmacológico da COVID-19 / Hipertensão Idioma: En Ano de publicação: 2021 Tipo de documento: Article