Comparative Analysis of Core and Accessory Genes in Coexpression Network.
Methods Mol Biol
; 2242: 45-58, 2021.
Article
em En
| MEDLINE
| ID: mdl-33961216
ABSTRACT
Prokaryotes harbor a various proportion of accessory genes in their genomes. The integration of accessory functions with the core regulation network is critical for environmental adaptation, particularly considering a theoretically unlimited number of niches on the earth for microorganisms. Comparative genomics can reveal a co-occurrence pattern between a subset of accessory genes (or variations in core genes) and an adaptation trait, while comparative transcriptomics can further uncover whether a coordinated regulation of gene expression is involved. In this chapter, we introduce a protocol for weighted gene coexpression network construction by using well-developed open source tools, and a further application of such a network in comparative analysis of bacterial core and accessory genes.
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MEDLINE
Assunto principal:
DNA Bacteriano
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Genoma Bacteriano
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Genômica
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Sinorhizobium fredii
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Redes Reguladoras de Genes
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article