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Synthesis and BK channel-opening activity of 2-amino-1,3-thiazole derivatives.
Qi, Xiao-Lei; Jo, Heeji; Wang, Xue-Ying; Ji, Tong-Tong; Lin, Hai-Xia; Park, Chul-Seung; Cui, Yong-Mei.
Afiliação
  • Qi XL; Department of Chemistry, Innovative Drug Research Center, College of Sciences, Shanghai University, Shanghai 200444, China.
  • Jo H; School of Life Sciences and National Leading Research Laboratory, Gwangju Institute of Science and Technology (GIST), Gwangju 61005, Republic of Korea.
  • Wang XY; Department of Chemistry, Innovative Drug Research Center, College of Sciences, Shanghai University, Shanghai 200444, China.
  • Ji TT; Department of Chemistry, Innovative Drug Research Center, College of Sciences, Shanghai University, Shanghai 200444, China.
  • Lin HX; Department of Chemistry, Innovative Drug Research Center, College of Sciences, Shanghai University, Shanghai 200444, China.
  • Park CS; School of Life Sciences and National Leading Research Laboratory, Gwangju Institute of Science and Technology (GIST), Gwangju 61005, Republic of Korea. Electronic address: cspark@gist.ac.kr.
  • Cui YM; Department of Chemistry, Innovative Drug Research Center, College of Sciences, Shanghai University, Shanghai 200444, China. Electronic address: ymcui@shu.edu.cn.
Bioorg Med Chem Lett ; 43: 128083, 2021 07 01.
Article em En | MEDLINE | ID: mdl-33964448
ABSTRACT
A series of 2-amino-5-arylmethyl- or 5-heteroarylmethyl-1,3-thiazole derivatives were synthesized and evaluated for BK channel-opening activities in cell-based fluorescence assay and electrophysiological recording. The assay results indicated that the activities of the investigated compounds were influenced by the physicochemical properties of the substituent at benzene ring.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tiazóis / Canais de Potássio Ativados por Cálcio de Condutância Alta Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tiazóis / Canais de Potássio Ativados por Cálcio de Condutância Alta Idioma: En Ano de publicação: 2021 Tipo de documento: Article