Altered distributions and functions of natural killer T cells and γδ T cells in neonates with neonatal encephalopathy, in school-age children at follow-up, and in children with cerebral palsy.
J Neuroimmunol
; 356: 577597, 2021 07 15.
Article
em En
| MEDLINE
| ID: mdl-33964735
ABSTRACT
We enumerated conventional and innate lymphocyte populations in neonates with neonatal encephalopathy (NE), school-age children post-NE, children with cerebral palsy and age-matched controls. Using flow cytometry, we demonstrate alterations in circulating T, B and natural killer cell numbers. Invariant natural killer T cell and Vδ2+ γδ T cell numbers and frequencies were strikingly higher in neonates with NE, children post-NE and children with cerebral palsy compared to age-matched controls, whereas mucosal-associated invariant T cells and Vδ1 T cells were depleted from children with cerebral palsy. Upon stimulation ex vivo, T cells, natural killer cells and Vδ2 T cells from neonates with NE more readily produced inflammatory cytokines than their counterparts from healthy neonates, suggesting that they were previously primed or activated. Thus, innate and conventional lymphocytes are numerically and functionally altered in neonates with NE and these changes may persist into school-age.
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Base de dados:
MEDLINE
Assunto principal:
Encefalopatias
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Paralisia Cerebral
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Receptores de Antígenos de Linfócitos T gama-delta
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Células T Matadoras Naturais
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article