Prolonged high-intensity exercise induces fluctuating immune responses to herpes simplex virus infection via glucocorticoids.
J Allergy Clin Immunol
; 148(6): 1575-1588.e7, 2021 12.
Article
em En
| MEDLINE
| ID: mdl-33965431
ABSTRACT
BACKGROUND:
Epidemiologic studies have yielded conflicting results regarding the influence of a single bout of prolonged high-intensity exercise on viral infection.OBJECTIVE:
We sought to learn whether prolonged high-intensity exercise either exacerbates or ameliorates herpes simplex virus type 2 (HSV-2) infection according to the interval between virus exposure and exercise.METHODS:
Mice were intravaginally infected with HSV-2 and exposed to run on the treadmill.RESULTS:
Prolonged high-intensity exercise 17 hours after infection impaired the clearance of HSV-2, while exercise 8 hours after infection enhanced the clearance of HSV-2. These impaired or enhanced immune responses were related to a transient decrease or increase in the number of blood-circulating plasmacytoid dendritic cells. Exercise-induced glucocorticoids transiently decreased the number of circulating plasmacytoid dendritic cells by facilitating their homing to the bone marrow via the CXCL12-CXCR4 axis, which led to their subsequent increase in the blood.CONCLUSION:
A single bout of prolonged high-intensity exercise can be either deleterious or beneficial to antiviral immunity.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Células Dendríticas
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Herpesvirus Humano 2
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Glucocorticoides
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Herpes Simples
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article