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Genetically edited CD34+ cells derived from human iPS cells in vivo but not in vitro engraft and differentiate into HIV-resistant cells.
Morvan, Maelig G; Teque, Fernando; Ye, Lin; Moreno, Mary E; Wang, Jiaming; VandenBerg, Scott; Stoddart, Cheryl A; Kan, Yuet Wai; Levy, Jay A.
Afiliação
  • Morvan MG; Department of Medicine, Division of Hematology and Oncology, University of California, San Francisco, CA 94143-1270.
  • Teque F; Department of Medicine, Division of Hematology and Oncology, University of California, San Francisco, CA 94143-1270.
  • Ye L; Department of Medicine, Institute of Human Genetics, University of California, San Francisco, CA 94143.
  • Moreno ME; Department of Medicine, Division of Experimental Medicine, San Francisco General Hospital, University of California, San Francisco, CA 94110.
  • Wang J; Department of Medicine, Institute of Human Genetics, University of California, San Francisco, CA 94143.
  • VandenBerg S; Helen Diller Family Comprehensive Cancer Center, Biorepository and Tissue Biomarker Technology Core, University of California, San Francisco, CA 94143-0875.
  • Stoddart CA; Department of Medicine, Division of Experimental Medicine, San Francisco General Hospital, University of California, San Francisco, CA 94110.
  • Kan YW; Department of Medicine, Institute of Human Genetics, University of California, San Francisco, CA 94143; yw.kan@ucsf.edu Jay.Levy@ucsf.edu.
  • Levy JA; Department of Medicine, Division of Hematology and Oncology, University of California, San Francisco, CA 94143-1270; yw.kan@ucsf.edu Jay.Levy@ucsf.edu.
Proc Natl Acad Sci U S A ; 118(20)2021 05 18.
Article em En | MEDLINE | ID: mdl-33975958
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco Hematopoéticas / Engenharia Genética / Infecções por HIV / Transplante de Células-Tronco Hematopoéticas / Células-Tronco Pluripotentes Induzidas Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco Hematopoéticas / Engenharia Genética / Infecções por HIV / Transplante de Células-Tronco Hematopoéticas / Células-Tronco Pluripotentes Induzidas Idioma: En Ano de publicação: 2021 Tipo de documento: Article