Pronounced anti-neuroinflammatory jasmonates and terpenes isolated from lychee seeds.
Fitoterapia
; 152: 104924, 2021 Jul.
Article
em En
| MEDLINE
| ID: mdl-33984432
ABSTRACT
Lychee is a favorite fruit of the Cantonese and native to Southeast Asia. In this study, the anti-neuroinflammatory bioactive compounds of lychee seeds have been carried out. Five new jasmonates (1, 2, 6-8) and seventeen known compounds were isolated using a series of chemical and chromatographic methods. Their chemical structures were identified through comprehensive spectroscopic analysis. Anti-neuroinflammatory activities were assayed and evaluated for the purified compounds. Most of the compounds exhibited pronounced anti-neuroinflammatory activities on nitric oxide (NO) induced by lipopolysaccharide (LPS) in BV-2 microglia cells. Moreover, compounds 1, 2 and 20 could reduce the expression of LPS-induced pro-inflammatory factors (iNOS and COX-2), inhibit the expression of mRNA levels of iNOS, COX-2, IL-6 and block NF-κB nuclear translocation in dose-dependent manners. This study suggested that lychee phytochemicals could be benefit to some neuroinflammatory-associated diseases, such as Alzheimer's disease.
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Base de dados:
MEDLINE
Assunto principal:
Terpenos
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Microglia
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Fármacos Neuroprotetores
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Ciclopentanos
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Litchi
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Oxilipinas
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Anti-Inflamatórios
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article