Overcoming Immunological Challenges Limiting Capsid-Mediated Gene Therapy With Machine Learning.

Wec, Anna Z; Lin, Kathy S; Kwasnieski, Jamie C; Sinai, Sam; Gerold, Jeff; Kelsic, Eric D

Wec, Anna Z; Lin, Kathy S; Kwasnieski, Jamie C; Sinai, Sam; Gerold, Jeff; Kelsic, Eric D.

Afiliação

Wec AZ; Applied Biology, Dyno Therapeutics Inc, Cambridge, MA, United States.
Lin KS; Data Science, Dyno Therapeutics Inc, Cambridge, MA, United States.
Kwasnieski JC; Applied Biology, Dyno Therapeutics Inc, Cambridge, MA, United States.
Sinai S; Data Science, Dyno Therapeutics Inc, Cambridge, MA, United States.
Gerold J; Data Science, Dyno Therapeutics Inc, Cambridge, MA, United States.
Kelsic ED; Applied Biology, Dyno Therapeutics Inc, Cambridge, MA, United States.

Front Immunol ; 12: 674021, 2021.

Article em En | MEDLINE | ID: mdl-33986759

Assuntos

Capsídeo/imunologia; Terapia Genética/métodos; Aprendizado de Máquina; Animais; Dependovirus; Vetores Genéticos; Humanos

Palavras-chave

AAV capsid design; gene therapy; immune evasion; machine learning; protein engineering

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Terapia Genética / Capsídeo / Aprendizado de Máquina Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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