[2.2]Paracyclophane-Based Isothiourea-Catalyzed Highly Enantioselective α-Fluorination of Carboxylic Acids.
Org Lett
; 23(11): 4142-4146, 2021 Jun 04.
Article
em En
| MEDLINE
| ID: mdl-33988375
ABSTRACT
Planar chiral [2.2]paracyclophane-based isothiourea catalysts have been prepared over a few simple steps in high yields. In the presence of these catalysts, highly efficient catalytic enantioselective fluorination of carboxylic acids has been accomplished, providing a broad range of optically active α-fluoroesters in high yield and excellent enantioselectivity.
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Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article