Photoacoustic-fluorescence microendoscopy in vivo.
Opt Lett
; 46(10): 2340-2343, 2021 May 15.
Article
em En
| MEDLINE
| ID: mdl-33988578
ABSTRACT
A miniature endoscope capable of imaging multiple tissue contrasts in high resolution is highly attractive, because it can provide complementary and detailed tissue information of internal organs. Here we present a photoacoustic (PA)-fluorescence (FL) endoscope for optical-resolution PA microscopy (PAM) and FL microscopy (FLM). The endoscope with a diameter of 2.8 mm achieves high lateral resolutions of 5.5 and 6.3 µm for PAM and FLM modes, respectively. In vivo imaging of zebrafish larvae and a mouse ear is conducted, and high-quality images are obtained. Additionally, in vivo endoscopic imaging of a rat rectum is demonstrated, showing the endoscopic imaging capability of our endoscope. By providing dual contrasts with high resolution, the endoscope may open up new opportunities for clinical endoscopic imaging applications.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Endoscópios
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Orelha
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Larva
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article