The role of OFD1 in selective autophagy.
Mol Cell Oncol
; 8(3): 1903291, 2021.
Article
em En
| MEDLINE
| ID: mdl-34027042
ABSTRACT
Autophagy is a cellular self-degradative pathway. Our study unveiled a novel mechanism mediated by OFD1, the protein mutated in Oral-Facial-Digital type I syndrome, based on selective degradation of autophagic proteins, which enables cells to calibrate their self-degradation. We demonstrated that unrestrained autophagy contributes to renal cysts observed in Ofd1 mutants.
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MEDLINE
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En
Ano de publicação:
2021
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Article