Biolistic Plastid Transformation in Lettuce (Lactuca sativa) for Oral Delivery of Biopharmaceuticals.
Methods Mol Biol
; 2317: 267-281, 2021.
Article
em En
| MEDLINE
| ID: mdl-34028775
ABSTRACT
The interest in producing pharmaceutical proteins in a nontoxic plant host has led to the development of an approach to express such proteins in transplastomic lettuce (Lactuca sativa). A number of therapeutic proteins and vaccine antigen candidates have been stably integrated into the lettuce plastid genome using biolistic DNA delivery. High levels of accumulation and retention of biological activity suggest that lettuce may provide and ideal platform for the production of biopharmaceuticals.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Transformação Genética
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Engenharia Genética
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Plantas Geneticamente Modificadas
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Plastídeos
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Folhas de Planta
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Lactuca
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Biolística
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article