JBIR-155, a Specific Class D ß-Lactamase Inhibitor of Microbial Origin.
Org Lett
; 23(11): 4415-4419, 2021 06 04.
Article
em En
| MEDLINE
| ID: mdl-34029112
ABSTRACT
We discovered JBIR-155 as a novel specific class D ß-lactamase inhibitor from Streptomyces polymachus SoB100815Hv02. JBIR-155 consists of a 6-oxabicyclo[3.2.0]heptan-7-one skeleton and a long unsaturated alkyl chain moiety of which absolute configuration was determined by spectroscopic data, modified Mosher's method, and analyses of the relative configuration of chemically modified derivative. JBIR-155 specifically exhibited inhibitory activity against the class D ß-lactamase, with an IC50 value of 0.36 µM.
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Base de dados:
MEDLINE
Assunto principal:
Streptomyces
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Inibidores de beta-Lactamases
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Antibacterianos
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article