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JBIR-155, a Specific Class D ß-Lactamase Inhibitor of Microbial Origin.
Nishimura, Takehiro; Kawahara, Teppei; Kagaya, Noritaka; Ogura, Yusuke; Takikawa, Hirosato; Suenaga, Hikaru; Adachi, Masaatsu; Hirokawa, Takatsugu; Doi, Takayuki; Shin-Ya, Kazuo.
Afiliação
  • Nishimura T; Technology Research Association for Next Generation Natural Products Chemistry, 2-4-7 Aomi, Koto-ku, Tokyo 135-0064, Japan.
  • Kawahara T; Japan Biological Informatics Consortium (JBIC), 2-4-7 Aomi, Koto-ku, Tokyo 135-0064 Japan.
  • Kagaya N; Technology Research Association for Next Generation Natural Products Chemistry, 2-4-7 Aomi, Koto-ku, Tokyo 135-0064, Japan.
  • Ogura Y; Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
  • Takikawa H; Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
  • Suenaga H; National Institute of Advanced Industrial Science and Technology (AIST), 2-4-7 Aomi, Koto-ku, Tokyo 135-0064, Japan.
  • Adachi M; Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aza-aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8578, Japan.
  • Hirokawa T; National Institute of Advanced Industrial Science and Technology (AIST), 2-4-7 Aomi, Koto-ku, Tokyo 135-0064, Japan.
  • Doi T; Division of Biomedical Science, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.
  • Shin-Ya K; Transborder Medical Research Center, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.
Org Lett ; 23(11): 4415-4419, 2021 06 04.
Article em En | MEDLINE | ID: mdl-34029112
ABSTRACT
We discovered JBIR-155 as a novel specific class D ß-lactamase inhibitor from Streptomyces polymachus SoB100815Hv02. JBIR-155 consists of a 6-oxabicyclo[3.2.0]heptan-7-one skeleton and a long unsaturated alkyl chain moiety of which absolute configuration was determined by spectroscopic data, modified Mosher's method, and analyses of the relative configuration of chemically modified derivative. JBIR-155 specifically exhibited inhibitory activity against the class D ß-lactamase, with an IC50 value of 0.36 µM.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Streptomyces / Inibidores de beta-Lactamases / Antibacterianos Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Streptomyces / Inibidores de beta-Lactamases / Antibacterianos Idioma: En Ano de publicação: 2021 Tipo de documento: Article