Dysregulation of long non-coding RNAs and their mechanisms in Huntington's disease.
J Neurosci Res
; 99(9): 2074-2090, 2021 09.
Article
em En
| MEDLINE
| ID: mdl-34031910
ABSTRACT
Extensive alterations in gene regulatory networks are a typical characteristic of Huntington's disease (HD); these include alterations in protein-coding genes and poorly understood non-coding RNAs (ncRNAs), which are associated with pathology caused by mutant huntingtin. Long non-coding RNAs (lncRNAs) are an important class of ncRNAs involved in a variety of biological functions, including transcriptional regulation and post-transcriptional modification of many targets, and likely contributed to the pathogenesis of HD. While a number of changes in lncRNAs expression have been observed in HD, little is currently known about their functions. Here, we discuss their possible mechanisms and molecular functions, with a particular focus on their roles in transcriptional regulation. These findings give us a better insight into HD pathogenesis and may provide new targets for the treatment of this neurodegenerative disease.
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Base de dados:
MEDLINE
Assunto principal:
Encéfalo
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Doença de Huntington
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Redes Reguladoras de Genes
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RNA Longo não Codificante
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Proteína Huntingtina
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article