Comparison of 4- and 4 plus-courses S-1 administration as adjuvant chemotherapy for pancreatic ductal adenocarcinoma.
BMC Cancer
; 21(1): 612, 2021 May 26.
Article
em En
| MEDLINE
| ID: mdl-34034684
ABSTRACT
PURPOSE:
The study aimed to investigate the potential benefit of more than 4 courses of S1 adjuvant chemotherapy for patients with pancreatic ductal adenocarcinoma (PDAC) after surgery.METHOD:
Data were retrospectively collected from consecutive patients who underwent S-1 adjuvant chemotherapy following curative pancreatectomy between January 2016 and December 2018. Four-courses and > 4 courses cohorts were compared for overall survival (OS) as a primary outcome, and relapse-free survival (RFS) and adverse event incidence as secondary outcomes.RESULTS:
Four-courses and > 4 courses cohorts comprised 99 patients and 64 ones, respectively. TNM stage (stage II vs. I HR, 2.125; 95% CI, 1.164-4.213; P = 0.015), duration of S-1 administration (4 vs. > 4 courses HR, 3.113; 95% CI, 1.531-6.327; P = 0.002) and tumor grade (G3 vs. G1/2 HR, 3.887; 95% CI, 1.922-7.861; P < 0.001) were independent prognostic factors. Under the condition of patients' survival time beyond 8 months, the OS of patients in > 4 courses cohort was significantly prolonged compared with that of 4 courses cohort (4 vs. > 4 courses HR, 2.284; 95% CI, 1.197-4.358; P = 0.012), especially for patients in TNM stageII (4 vs. > 4 courses HR, 2.906; 95% CI, 1.275-6.623; P = 0.011).RFS and adverse events incidence did not signifcantly difer between both cohorts.CONCLUSION:
Prolonged duration of S-1 intake is beneficial to prognosis of patients with PDAC resection.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Ácido Oxônico
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Pancreatectomia
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Neoplasias Pancreáticas
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Tegafur
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Carcinoma Ductal Pancreático
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Recidiva Local de Neoplasia
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Antimetabólitos Antineoplásicos
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article