Immune evasion of SARS-CoV-2 variants of concern is driven by low affinity to neutralizing antibodies.
Chem Commun (Camb)
; 57(49): 6094-6097, 2021 Jun 21.
Article
em En
| MEDLINE
| ID: mdl-34037640
ABSTRACT
SARS-CoV-2 VOC immune evasion is mainly due to lower cross-reactivity from previously elicited class I/II neutralizing antibodies, while increased affinity to hACE2 plays a minor role. The affinity between antibodies and VOCs is impacted by remodeling of the electrostatic surface potential of the Spike RBDs. The P.3 variant is a putative VOC.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Anticorpos Neutralizantes
/
Evasão da Resposta Imune
/
SARS-CoV-2
/
Afinidade de Anticorpos
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article