Impact of Diverse Ion Channels on Regulatory T Cell Functions.
Cell Physiol Biochem
; 55(S3): 145-156, 2021 May 28.
Article
em En
| MEDLINE
| ID: mdl-34043301
ABSTRACT
The population of regulatory T cells (Tregs) is critical for immunological self-tolerance and homeostasis. Proper ion regulation contributes to Treg lineage identity, regulation, and effector function. Identified ion channels include Ca2+ release-activated Ca2+, transient receptor potential, P2X, volume-regulated anion and K+ channels Kv1.3 and KCa3.1. Ion channel modulation represents a promising therapeutic approach for the treatment of autoimmune diseases such as rheumatoid arthritis and multiple sclerosis. This review summarizes studies with gene-targeted mice and pharmacological modulators affecting Treg number and function. Furthermore, participation of ion channels is illustrated and the power of future research possibilities is discussed.
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MEDLINE
Assunto principal:
Artrite Reumatoide
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Regulação da Expressão Gênica
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Cálcio
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Linfócitos T Reguladores
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Moduladores de Transporte de Membrana
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Esclerose Múltipla
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article