The DNMT3A PWWP domain is essential for the normal DNA methylation landscape in mouse somatic cells and oocytes.

Kibe, Kanako; Shirane, Kenjiro; Ohishi, Hiroaki; Uemura, Shuhei; Toh, Hidehiro; Sasaki, Hiroyuki

Kibe, Kanako; Shirane, Kenjiro; Ohishi, Hiroaki; Uemura, Shuhei; Toh, Hidehiro; Sasaki, Hiroyuki.

Afiliação

Kibe K; Division of Epigenomics and Development, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Shirane K; Division of Epigenomics and Development, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Ohishi H; Department of Stem Cell Biology and Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Uemura S; Division of Epigenomics and Development, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Toh H; Graduate School of Integrated Science for Life, Hiroshima University, Higashi-Hiroshima, Japan.
Sasaki H; Division of Epigenomics and Development, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.

PLoS Genet ; 17(5): e1009570, 2021 05.

Article em En | MEDLINE | ID: mdl-34048432

Assuntos

DNA (Citosina-5-)-Metiltransferases/química; DNA (Citosina-5-)-Metiltransferases/metabolismo; Metilação de DNA; Mutação; Oócitos/metabolismo; Domínios Proteicos; Substituição de Aminoácidos; Animais; DNA (Citosina-5-)-Metiltransferases/genética; DNA Metiltransferase 3A; Feminino; Histonas/química; Histonas/metabolismo; Masculino; Camundongos; Fenótipo; Domínios Proteicos/genética; Transcriptoma

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oócitos / Metilação de DNA / DNA (Citosina-5-)-Metiltransferases / Domínios Proteicos / Mutação Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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