A Metastatic Neuroblastic Tumor in a 28-Month-old Boy: Unusual Spontaneous Regression From Neuroblastoma to Ganglioneuroma?
J Pediatr Hematol Oncol
; 44(2): e589-e592, 2022 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-34054050
ABSTRACT
Neuroblastoma with bone metastasis is well known to have an extremely poor prognosis. We experienced the case of a patient with adrenal ganglioneuroblastoma (GNB) with metastases of subcutaneous nodules, a lymph node, and multiple bones. A pathologic examination of tumors from different sites revealed both GNB and ganglioneuroma. A genetic comparison between these tumors identified the same molecular signatures, suggesting the possibility of spontaneous differentiation in the remaining GNB. The patient has been healthy without aggressive chemotherapy, and the patient's pathologic urinary catecholamines normalized. Even if unusual, we have to recognize probable spontaneous differentiation from neuroblastoma to GNB and then to ganglioneuroma, even in sites of bone metastasis.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias das Glândulas Suprarrenais
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Ganglioneuroblastoma
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Ganglioneuroma
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Neuroblastoma
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article