Heterocycles as a Peptidomimetic Scaffold: Solid-Phase Synthesis Strategies.
Pharmaceuticals (Basel)
; 14(5)2021 May 10.
Article
em En
| MEDLINE
| ID: mdl-34068671
ABSTRACT
Peptidomimetics are a privileged class of pharmacophores that exhibit improved physicochemical and biological properties. Solid-phase synthesis is a powerful tool for gaining rapid access to libraries of molecules from small molecules to biopolymers and also is widely used for the synthesis of peptidomimetics. Small molecules including heterocycles serve as a core for hundreds of drugs, including peptidomimetic molecules. This review covers solid-phase synthesis strategies for peptidomimetics molecules based on heterocycles.
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MEDLINE
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article