Relevance of primary lesion location, tumour heterogeneity and genetic mutation demonstrated through tumour growth inhibition and overall survival modelling in metastatic colorectal cancer.

Vera-Yunca, Diego; Parra-Guillen, Zinnia P; Girard, Pascal; Trocóniz, Iñaki F; Terranova, Nadia

Vera-Yunca, Diego; Parra-Guillen, Zinnia P; Girard, Pascal; Trocóniz, Iñaki F; Terranova, Nadia.

Afiliação

Vera-Yunca D; Pharmacometrics & Systems Pharmacology, Department of Pharmaceutical Technology and Chemistry, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain.
Parra-Guillen ZP; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain.
Girard P; Pharmacometrics & Systems Pharmacology, Department of Pharmaceutical Technology and Chemistry, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain.
Trocóniz IF; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain.
Terranova N; Merck Serono S.A., Switzerland, an affiliate of Merck KGaA, Merck Institute for Pharmacometrics, Darmstadt, Germany.

Br J Clin Pharmacol ; 88(1): 166-177, 2022 01.

Article em En | MEDLINE | ID: mdl-34087010

Assuntos

Neoplasias Colorretais; Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico; Cetuximab/uso terapêutico; Neoplasias Colorretais/tratamento farmacológico; Neoplasias Colorretais/genética; Neoplasias Colorretais/patologia; Intervalo Livre de Doença; Humanos; Mutação; Análise de Sobrevida

Palavras-chave

KRAS mutation; cetuximab; metastatic colorectal cancer; survival analysis; tumour heterogeneity; tumour location; tumour size modelling

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais Idioma: En Ano de publicação: 2022 Tipo de documento: Article