The bioinformatics and metabolomics research on anti-hypoxic molecular mechanisms of Salidroside via regulating the PTEN mediated PI3K/Akt/NF-&#954;B signaling pathway.

Wu, Yi; Ma, Yi; Li, Jing; Zhou, Xue-Lin; Li, Lei; Xu, Ping-Xiang; Li, Xiao-Rong; Xue, Ming

The bioinformatics and metabolomics research on anti-hypoxic molecular mechanisms of Salidroside via regulating the PTEN mediated PI3K/Akt/NF-κB signaling pathway.

Wu, Yi; Ma, Yi; Li, Jing; Zhou, Xue-Lin; Li, Lei; Xu, Ping-Xiang; Li, Xiao-Rong; Xue, Ming.

Afiliação

Wu Y; Department of Pharmacology, Beijing Laboratory for Biomedical Detection Technology and Instrument, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Ma Y; Department of Pharmacology, Beijing Laboratory for Biomedical Detection Technology and Instrument, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Li J; Department of Pharmacology, Beijing Laboratory for Biomedical Detection Technology and Instrument, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Zhou XL; Department of Pharmacology, Beijing Laboratory for Biomedical Detection Technology and Instrument, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China; Beijing Engineering Research Center for Nerve System Drugs, Beijing 100053, China.
Li L; Central Laboratory, Capital Medical University, Beijing 100069, China.
Xu PX; Department of Pharmacology, Beijing Laboratory for Biomedical Detection Technology and Instrument, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China; Beijing Engineering Research Center for Nerve System Drugs, Beijing 100053, China.
Li XR; Department of Pharmacology, Beijing Laboratory for Biomedical Detection Technology and Instrument, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China; Beijing Engineering Research Center for Nerve System Drugs, Beijing 100053, China. Electronic address: madingdaier@a
Xue M; Department of Pharmacology, Beijing Laboratory for Biomedical Detection Technology and Instrument, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China; Beijing Engineering Research Center for Nerve System Drugs, Beijing 100053, China. Electronic address: xuem@ccmu.edu

Chin J Nat Med ; 19(6): 442-453, 2021 Jun.

Article em En | MEDLINE | ID: mdl-34092295

Assuntos

Hipóxia Celular/efeitos dos fármacos; Glucosídeos/farmacologia; Fenóis/farmacologia; Fosfatidilinositol 3-Quinases; Proteínas Proto-Oncogênicas c-akt; Transdução de Sinais/efeitos dos fármacos; Animais; Biologia Computacional; Metabolômica; NF-kappa B/genética; NF-kappa B/metabolismo; Células PC12; PTEN Fosfo-Hidrolase/genética; PTEN Fosfo-Hidrolase/metabolismo; Fosfatidilinositol 3-Quinases/genética; Fosfatidilinositol 3-Quinases/metabolismo; Proteínas Proto-Oncogênicas c-akt/genética; Proteínas Proto-Oncogênicas c-akt/metabolismo; Ratos

Palavras-chave

Hypoxia; Metabolomics; PC12; PI3K/Akt/NF-κB; PTEN; Salidroside

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fenóis / Transdução de Sinais / Hipóxia Celular / Fosfatidilinositol 3-Quinases / Proteínas Proto-Oncogênicas c-akt / Glucosídeos Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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