Intra- and intercellular signaling pathways associated with drug-induced cardiac pathophysiology.
Trends Pharmacol Sci
; 42(8): 675-687, 2021 08.
Article
em En
| MEDLINE
| ID: mdl-34092416
ABSTRACT
Cardiac physiology and homeostasis are maintained by the interaction of multiple cell types, via both intra- and intercellular signaling pathways. Perturbations in these signaling pathways induced by oncology therapies can reduce cardiac function, ultimately leading to heart failure. As cancer survival increases, related cardiovascular complications are becoming increasingly prevalent, thus identifying the perturbations and cell signaling drivers of cardiotoxicity is increasingly important. Here, we discuss the homotypic and heterotypic cellular interactions that form the basis of intra- and intercellular cardiac signaling pathways, and how oncological agents disrupt these pathways, leading to heart failure. We also highlight the emerging systems biology techniques that can be applied, enabling a deeper understanding of the intra- and intercellular signaling pathways across multiple cell types associated with cardiovascular toxicity.
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Base de dados:
MEDLINE
Assunto principal:
Preparações Farmacêuticas
/
Cardiopatias
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article