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GIPR antagonist antibodies conjugated to GLP-1 peptide are bispecific molecules that decrease weight in obese mice and monkeys.
Lu, Shu-Chen; Chen, Michelle; Atangan, Larissa; Killion, Elizabeth A; Komorowski, Renee; Cheng, Yuan; Netirojjanakul, Chawita; Falsey, James R; Stolina, Marina; Dwyer, Denise; Hale, Clarence; Stanislaus, Shanaka; Hager, Todd; Thomas, Veena A; Harrold, John M; Lloyd, David J; Véniant, Murielle M.
Afiliação
  • Lu SC; Amgen Research, Department of Cardiometabolic Disorders, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA.
  • Chen M; Amgen Research, Department of Cardiometabolic Disorders, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA.
  • Atangan L; Amgen Research, Department of Cardiometabolic Disorders, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA.
  • Killion EA; Amgen Research, Department of Cardiometabolic Disorders, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA.
  • Komorowski R; Amgen Research, Department of Cardiometabolic Disorders, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA.
  • Cheng Y; Amgen Research, Department of Therapeutic Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA.
  • Netirojjanakul C; Amgen Research, Department of Therapeutic Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA.
  • Falsey JR; Amgen Research, Department of Therapeutic Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA.
  • Stolina M; Amgen Research, Department of Cardiometabolic Disorders, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA.
  • Dwyer D; Amgen Research, Department of Cardiometabolic Disorders, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA.
  • Hale C; Amgen Research, Department of Cardiometabolic Disorders, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA.
  • Stanislaus S; Amgen Research, Department of Cardiometabolic Disorders, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA.
  • Hager T; Amgen Research, Department of Translational Safety & Bioanalytical Sciences, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA.
  • Thomas VA; Amgen Research, Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., 1140 Veterans Boulevard, South San Francisco, CA 94080, USA.
  • Harrold JM; Amgen Research, Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., 1140 Veterans Boulevard, South San Francisco, CA 94080, USA.
  • Lloyd DJ; Amgen Research, Department of Cardiometabolic Disorders, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA.
  • Véniant MM; Amgen Research, Department of Cardiometabolic Disorders, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA.
Cell Rep Med ; 2(5): 100263, 2021 05 18.
Article em En | MEDLINE | ID: mdl-34095876
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peso Corporal / Receptores dos Hormônios Gastrointestinais / Peptídeo 1 Semelhante ao Glucagon / Obesidade Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peso Corporal / Receptores dos Hormônios Gastrointestinais / Peptídeo 1 Semelhante ao Glucagon / Obesidade Idioma: En Ano de publicação: 2021 Tipo de documento: Article