A novel class for carbonic anhydrases inhibitors and evaluation of their non-zinc binding.
Arch Pharm (Weinheim)
; 354(10): e2100188, 2021 Oct.
Article
em En
| MEDLINE
| ID: mdl-34096646
ABSTRACT
In this study, 23 different imidazole derivatives were synthesized, and the inhibitory properties of these derivatives against carbonic anhydrase I and II isoenzymes were investigated for the first time. The inhibition concentrations of the imidazole derivatives were found to be in the range of 2.89-115.5 nM. Docking studies examined the binding properties of the imidazole derivatives, and the structure-activity relationship is discussed. Theoretical calculations showed that the binding mode of the imidazole ring was non-zinc binding.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Inibidores da Anidrase Carbônica
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Anidrase Carbônica I
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Anidrase Carbônica II
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Imidazóis
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article