Combining High-Throughput Synthesis and High-Throughput Protein Crystallography for Accelerated Hit Identification.

Sutanto, Fandi; Shaabani, Shabnam; Oerlemans, Rick; Eris, Deniz; Patil, Pravin; Hadian, Mojgan; Wang, Meitian; Sharpe, May Elizabeth; Groves, Matthew R; Dömling, Alexander

Sutanto, Fandi; Shaabani, Shabnam; Oerlemans, Rick; Eris, Deniz; Patil, Pravin; Hadian, Mojgan; Wang, Meitian; Sharpe, May Elizabeth; Groves, Matthew R; Dömling, Alexander.

Afiliação

Sutanto F; University of Groningen, Department of Drug Design, A. Deusinglaan 1, 9713, AV, Groningen, The Netherlands.
Shaabani S; University of Groningen, Department of Drug Design, A. Deusinglaan 1, 9713, AV, Groningen, The Netherlands.
Oerlemans R; University of Groningen, Department of Drug Design, A. Deusinglaan 1, 9713, AV, Groningen, The Netherlands.
Eris D; Photon Science Division, Paul Scherrer Institute, Switzerland.
Patil P; University of Groningen, Department of Drug Design, A. Deusinglaan 1, 9713, AV, Groningen, The Netherlands.
Hadian M; University of Groningen, Department of Drug Design, A. Deusinglaan 1, 9713, AV, Groningen, The Netherlands.
Wang M; Photon Science Division, Paul Scherrer Institute, Switzerland.
Sharpe ME; Photon Science Division, Paul Scherrer Institute, Switzerland.
Groves MR; University of Groningen, Department of Drug Design, A. Deusinglaan 1, 9713, AV, Groningen, The Netherlands.
Dömling A; University of Groningen, Department of Drug Design, A. Deusinglaan 1, 9713, AV, Groningen, The Netherlands.

Angew Chem Int Ed Engl ; 60(33): 18231-18239, 2021 08 09.

Article em En | MEDLINE | ID: mdl-34097796

Assuntos

Proteases 3C de Coronavírus/metabolismo; Inibidores de Cisteína Proteinase/metabolismo; Bibliotecas de Moléculas Pequenas/metabolismo; Acrilamidas/síntese química; Acrilamidas/metabolismo; Acrilatos/síntese química; Acrilatos/metabolismo; Domínio Catalítico; Proteases 3C de Coronavírus/antagonistas & inibidores; Proteases 3C de Coronavírus/química; Cristalografia por Raios X; Inibidores de Cisteína Proteinase/síntese química; Descoberta de Drogas; Ensaios de Triagem em Larga Escala; Ligação Proteica; SARS-CoV-2/química; Bibliotecas de Moléculas Pequenas/síntese química

Palavras-chave

SARS-CoV-2; covalent inhibitors; high-throughput protein crystallography; multicomponent reactions; nanosynthesis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores de Cisteína Proteinase / Bibliotecas de Moléculas Pequenas / Proteases 3C de Coronavírus Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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