Identification of lymphocyte cell-specific protein-tyrosine kinase (LCK) as a driver for invasion and migration of oral cancer by tumor heterogeneity exploitation.

Weiße, Jonas; Rosemann, Julia; Müller, Lisa; Kappler, Matthias; Eckert, Alexander W; Glaß, Markus; Misiak, Danny; Hüttelmaier, Stefan; Ballhausen, Wolfgang G; Hatzfeld, Mechthild; Haemmerle, Monika; Gutschner, Tony

Weiße, Jonas; Rosemann, Julia; Müller, Lisa; Kappler, Matthias; Eckert, Alexander W; Glaß, Markus; Misiak, Danny; Hüttelmaier, Stefan; Ballhausen, Wolfgang G; Hatzfeld, Mechthild; Haemmerle, Monika; Gutschner, Tony.

Afiliação

Weiße J; Junior Research Group 'RNA biology and pathogenesis', Faculty of Medicine, Martin Luther University Halle-Wittenberg, 06120, Halle, Germany.
Rosemann J; Junior Research Group 'RNA biology and pathogenesis', Faculty of Medicine, Martin Luther University Halle-Wittenberg, 06120, Halle, Germany.
Müller L; Institute of Molecular Medicine, Section for Pathobiochemistry, Faculty of Medicine, Martin Luther University Halle-Wittenberg, 06120, Halle, Germany.
Kappler M; Department of Oral and Maxillofacial Plastic Surgery, Faculty of Medicine, Martin Luther University Halle-Wittenberg, 06120, Halle, Germany.
Eckert AW; Department of Cranio Maxillofacial Surgery, Paracelsus Medical University, 90471, Nuremberg, Germany.
Glaß M; Institute of Molecular Medicine, Section for Molecular Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, 06120, Halle, Germany.
Misiak D; Institute of Molecular Medicine, Section for Molecular Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, 06120, Halle, Germany.
Hüttelmaier S; Institute of Molecular Medicine, Section for Molecular Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, 06120, Halle, Germany.
Ballhausen WG; Institute of Molecular Medicine, Section for Molecular Oncology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, 06120, Halle, Germany.
Hatzfeld M; Institute of Molecular Medicine, Section for Pathobiochemistry, Faculty of Medicine, Martin Luther University Halle-Wittenberg, 06120, Halle, Germany.
Haemmerle M; Institute of Pathology, Section for Experimental Pathology, Medical Faculty, Martin Luther University Halle-Wittenberg, 06112, Halle, Germany.
Gutschner T; Junior Research Group 'RNA biology and pathogenesis', Faculty of Medicine, Martin Luther University Halle-Wittenberg, 06120, Halle, Germany. tony.gutschner@uk-halle.de.

Mol Cancer ; 20(1): 88, 2021 06 11.

Article em En | MEDLINE | ID: mdl-34116687

Assuntos

Carcinoma de Células Escamosas/patologia; Proteína Tirosina Quinase p56(lck) Linfócito-Específica/genética; Neoplasias Bucais/patologia; Invasividade Neoplásica/genética; Antineoplásicos/farmacologia; Carcinoma de Células Escamosas/genética; Linhagem Celular Tumoral; Movimento Celular/efeitos dos fármacos; Movimento Celular/genética; Dasatinibe/farmacologia; Humanos; Neoplasias Bucais/genética; Invasividade Neoplásica/patologia; Transcriptoma

Palavras-chave

Clonal heterogeneity; Dasatinib; EMT; HNSCC; ITH; Invasion; Metastasis; OSCC; Src

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Bucais / Carcinoma de Células Escamosas / Proteína Tirosina Quinase p56(lck) Linfócito-Específica / Invasividade Neoplásica Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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