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A multicomponent tetrazolo indole synthesis.
Lei, Xiaofang; Lampiri, Panagiota; Patil, Pravin; Angeli, Giasemi; Neochoritis, Constantinos G; Dömling, Alexander.
Afiliação
  • Lei X; University of Crete, Department of Chemistry, Heraklion, Greece. kneochor@uoc.gr and University of Groningen, Department of Pharmacy, Drug Design group, Groningen, The Netherlands. a.s.s.domling@rug.nl.
  • Lampiri P; University of Crete, Department of Chemistry, Heraklion, Greece. kneochor@uoc.gr.
  • Patil P; University of Groningen, Department of Pharmacy, Drug Design group, Groningen, The Netherlands. a.s.s.domling@rug.nl.
  • Angeli G; University of Crete, Department of Chemistry, Heraklion, Greece. kneochor@uoc.gr.
  • Neochoritis CG; University of Crete, Department of Chemistry, Heraklion, Greece. kneochor@uoc.gr.
  • Dömling A; University of Groningen, Department of Pharmacy, Drug Design group, Groningen, The Netherlands. a.s.s.domling@rug.nl.
Chem Commun (Camb) ; 57(54): 6652-6655, 2021 Jul 06.
Article em En | MEDLINE | ID: mdl-34128009
ABSTRACT
The ubiquitous presence of the indole fragment in natural products and drugs asks for ever novel syntheses. We report an unprecedented mild, two-step synthesis of 2-tetrazolo substituted indoles based on the Ugi-tetrazole reaction combined with an acidic ring closure. A gram-scale synthesis, a bioactive compound and further transformations were performed.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article