Exploration and validation of hub genes and pathways in the progression of hypoplastic left heart syndrome via weighted gene co-expression network analysis.

Liu, Xuelan; Shang, Honglei; Li, Bin; Zhao, Liyun; Hua, Ying; Wu, Kaiyuan; Hu, Manman; Fan, Taibing

Liu, Xuelan; Shang, Honglei; Li, Bin; Zhao, Liyun; Hua, Ying; Wu, Kaiyuan; Hu, Manman; Fan, Taibing.

Afiliação

Liu X; Department of Children's Heart Center, Henan Provincial People's Hospital, Department of Children's Heart Center of Fuwai Central China Cardiovascular Hospital, Central China Fuwai Hospital of Zhengzhou University, Zhengzhou, 450003, Henan, China.
Shang H; Department of Radiology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Li B; Department of Children's Heart Center, Henan Provincial People's Hospital, Department of Children's Heart Center of Fuwai Central China Cardiovascular Hospital, Central China Fuwai Hospital of Zhengzhou University, Zhengzhou, 450003, Henan, China.
Zhao L; Department of Children's Heart Center, Henan Provincial People's Hospital, Department of Children's Heart Center of Fuwai Central China Cardiovascular Hospital, Central China Fuwai Hospital of Zhengzhou University, Zhengzhou, 450003, Henan, China.
Hua Y; Department of Children's Heart Center, Henan Provincial People's Hospital, Department of Children's Heart Center of Fuwai Central China Cardiovascular Hospital, Central China Fuwai Hospital of Zhengzhou University, Zhengzhou, 450003, Henan, China.
Wu K; Department of Children's Heart Center, Henan Provincial People's Hospital, Department of Children's Heart Center of Fuwai Central China Cardiovascular Hospital, Central China Fuwai Hospital of Zhengzhou University, Zhengzhou, 450003, Henan, China.
Hu M; Department of Children's Heart Center, Henan Provincial People's Hospital, Department of Children's Heart Center of Fuwai Central China Cardiovascular Hospital, Central China Fuwai Hospital of Zhengzhou University, Zhengzhou, 450003, Henan, China.
Fan T; Department of Children's Heart Center, Henan Provincial People's Hospital, Department of Children's Heart Center of Fuwai Central China Cardiovascular Hospital, Central China Fuwai Hospital of Zhengzhou University, Zhengzhou, 450003, Henan, China. fantaibing@163.com.

BMC Cardiovasc Disord ; 21(1): 300, 2021 06 15.

Article em En | MEDLINE | ID: mdl-34130651

Assuntos

Perfilação da Expressão Gênica; Redes Reguladoras de Genes; Síndrome do Coração Esquerdo Hipoplásico/genética; RNA Mensageiro/genética; Transcriptoma; Animais; Estudos de Casos e Controles; Bases de Dados Genéticas; Modelos Animais de Doenças; Predisposição Genética para Doença; Humanos; Síndrome do Coração Esquerdo Hipoplásico/diagnóstico por imagem; Síndrome do Coração Esquerdo Hipoplásico/metabolismo; Camundongos; Fenótipo; Mapas de Interação de Proteínas; RNA Mensageiro/metabolismo; Reprodutibilidade dos Testes; Transdução de Sinais

Palavras-chave

Hub genes; Hypoplastic left heart syndrome; Pathways; Proteinprotein interaction network; Weighted gene co-expression network analysis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: RNA Mensageiro / Síndrome do Coração Esquerdo Hipoplásico / Perfilação da Expressão Gênica / Redes Reguladoras de Genes / Transcriptoma Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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