Euglycaemic ketoacidosis in pregnant women with COVID-19: two case reports.
BMC Pregnancy Childbirth
; 21(1): 427, 2021 Jun 16.
Article
em En
| MEDLINE
| ID: mdl-34134652
ABSTRACT
BACKGROUND:
Euglycaemic ketoacidosis (EKA) is an infrequent but serious condition which usually follows a period of starvation, severe vomiting or illness in individuals with or without diabetes. Ketoacidosis is associated with materno-fetal morbidity and mortality necessitating prompt diagnosis and management. Physiological increases in insulin resistance render pregnancy a diabetogenic state with increased susceptibility to ketosis. COVID-19 is associated with worse clinical outcomes in patients with diabetes and is an independent risk factor for ketoacidosis in normoglycaemic individuals. CASE PRESENTATIONS We describe two cases of SARS-CoV-2 positive pregnant women presenting with normoglycaemic metabolic ketoacidosis. Both cases were associated with maternal and fetal compromise, requiring aggressive fluid and insulin resuscitation and early delivery.CONCLUSION:
We discuss possible physiology and propose a management strategy for euglycaemic ketoacidosis in pregnancy.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Complicações na Gravidez
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Inanição
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COVID-19
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Cetose
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article