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Glucocorticoid receptor signaling in ventral tegmental area neurons increases the rewarding value of a high-fat diet in mice.
Mizoguchi, Akira; Banno, Ryoichi; Sun, Runan; Yaginuma, Hiroshi; Taki, Keigo; Kobayashi, Tomoko; Sugiyama, Mariko; Tsunekawa, Taku; Onoue, Takeshi; Takagi, Hiroshi; Hagiwara, Daisuke; Ito, Yoshihiro; Iwama, Shintaro; Suga, Hidetaka; Nagai, Taku; Yamada, Kiyofumi; Arima, Hiroshi.
Afiliação
  • Mizoguchi A; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Turumai-cho, Showa-ku, Nagoya, Aichi, 466-8560, Japan.
  • Banno R; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Turumai-cho, Showa-ku, Nagoya, Aichi, 466-8560, Japan. ryouichi@med.nagoya-u.ac.jp.
  • Sun R; Physical Fitness and Sports, Research Center of Health, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi, 464-0814, Japan. ryouichi@med.nagoya-u.ac.jp.
  • Yaginuma H; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Turumai-cho, Showa-ku, Nagoya, Aichi, 466-8560, Japan.
  • Taki K; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Turumai-cho, Showa-ku, Nagoya, Aichi, 466-8560, Japan.
  • Kobayashi T; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Turumai-cho, Showa-ku, Nagoya, Aichi, 466-8560, Japan.
  • Sugiyama M; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Turumai-cho, Showa-ku, Nagoya, Aichi, 466-8560, Japan.
  • Tsunekawa T; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Turumai-cho, Showa-ku, Nagoya, Aichi, 466-8560, Japan.
  • Onoue T; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Turumai-cho, Showa-ku, Nagoya, Aichi, 466-8560, Japan.
  • Takagi H; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Turumai-cho, Showa-ku, Nagoya, Aichi, 466-8560, Japan.
  • Hagiwara D; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Turumai-cho, Showa-ku, Nagoya, Aichi, 466-8560, Japan.
  • Ito Y; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Turumai-cho, Showa-ku, Nagoya, Aichi, 466-8560, Japan.
  • Iwama S; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Turumai-cho, Showa-ku, Nagoya, Aichi, 466-8560, Japan.
  • Suga H; Department of CKD Initiatives/Nephrology, Nagoya University Graduate School of Medicine, 65 Turumai-cho, Showa-ku, Nagoya, Aichi, 466-8560, Japan.
  • Nagai T; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Turumai-cho, Showa-ku, Nagoya, Aichi, 466-8560, Japan.
  • Yamada K; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Turumai-cho, Showa-ku, Nagoya, Aichi, 466-8560, Japan.
  • Arima H; Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, 65 Turumai-cho, Showa-ku, Nagoya, Aichi, 466-8560, Japan.
Sci Rep ; 11(1): 12873, 2021 06 18.
Article em En | MEDLINE | ID: mdl-34145364
ABSTRACT
The reward system, which consists of dopaminergic neurons projecting from the ventral tegmental area (VTA) to the nucleus accumbens and caudate-putamen in the striatum, has an important role in the pathogenesis of not only drug addiction but also diet-induced obesity. In the present study, we examined whether signaling through glucocorticoid receptors (GRs) in the reward system affects the rewarding value of a high-fat diet (HFD). To do so, we generated mice that lack functional GRs specifically in dopaminergic neurons (D-KO mice) or corticostriatal neurons (CS-KO mice), subjected the mice to caloric restriction stress conditions, and evaluated the rewarding value of a HFD by conditioned place preference (CPP) test. Caloric restriction induced increases in serum corticosterone to similar levels in all genotypes. While CS-KO as well as WT mice exhibited a significant preference for HFD in the CPP test, D-KO mice exhibited no such preference. There were no differences between WT and D-KO mice in consumption of HFD after fasting or cognitive function evaluated by a novel object recognition test. These data suggest that glucocorticoid signaling in the VTA increases the rewarding value of a HFD under restricted caloric stress.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Recompensa / Transdução de Sinais / Receptores de Glucocorticoides / Área Tegmentar Ventral / Dieta Hiperlipídica / Neurônios Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Recompensa / Transdução de Sinais / Receptores de Glucocorticoides / Área Tegmentar Ventral / Dieta Hiperlipídica / Neurônios Idioma: En Ano de publicação: 2021 Tipo de documento: Article