Tirapazamine suppress osteosarcoma cells in part through SLC7A11 mediated ferroptosis.

Shi, Yihua; Gong, Ming; Deng, Zhouming; Liu, Huifan; Chang, Yiqiang; Yang, Zhiqiang; Cai, Lin

Shi, Yihua; Gong, Ming; Deng, Zhouming; Liu, Huifan; Chang, Yiqiang; Yang, Zhiqiang; Cai, Lin.

Afiliação

Shi Y; Department of Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.
Gong M; Department of Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.
Deng Z; Department of Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.
Liu H; Department of Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.
Chang Y; Department of Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.
Yang Z; Department of Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.
Cai L; Department of Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China. Electronic address: orthopedics@whu.edu.cn.

Biochem Biophys Res Commun ; 567: 118-124, 2021 08 27.

Article em En | MEDLINE | ID: mdl-34147710

Assuntos

Sistema y+ de Transporte de Aminoácidos/metabolismo; Antineoplásicos/farmacologia; Neoplasias Ósseas/tratamento farmacológico; Ferroptose/efeitos dos fármacos; Osteossarcoma/tratamento farmacológico; Tirapazamina/farmacologia; Neoplasias Ósseas/metabolismo; Linhagem Celular Tumoral; Humanos; Osteossarcoma/metabolismo

Palavras-chave

Ferroptosis; Osteosarcoma; SLC7A11; TPZ

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Ósseas / Osteossarcoma / Sistema y/ de Transporte de Aminoácidos / Tirapazamina / Ferroptose / Antineoplásicos Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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