Radiotherapy-induced tumor lysis syndrome in a dog with thymoma.
J Vet Med Sci
; 83(8): 1290-1294, 2021 Aug 26.
Article
em En
| MEDLINE
| ID: mdl-34148912
ABSTRACT
A 13-year-old, female, mixed-breed dog with a huge cranial mediastinal mass underwent radiotherapy (RT). On the following day, the dog presented with lethargy and anorexia. Hematological examination revealed elevated levels of blood urea nitrogen, creatinine, inorganic phosphorus, potassium, lactate dehydrogenase, creatine phosphokinase and aspartate aminotransferase, decreased calcium level, and metabolic acidosis. Urine output markedly decreased. The patient recovered with fluid therapy and diuretic therapy; however, died suddenly from an unknown cause 11 days after RT completion. Histopathological examination after necropsy showed thymoma in the cranial mediastinum and extensive tubular necrosis of both kidneys which may be due to RT-induced tumor lysis syndrome (TLS). This report suggests that the risk of TLS should be evaluated in dogs with thymoma who undergo RT.
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Base de dados:
MEDLINE
Assunto principal:
Timoma
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Neoplasias do Timo
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Síndrome de Lise Tumoral
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Doenças do Cão
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article